Blaze and the Monster Machines plays on Nickelodeon's Nick Jr. block, and the Nick Jr. channel, which are both widely available on cable and satellite in the United States. Nickelodeon and Nick Jr. in other nations also carry the program.

The series follows their adventures in Axle City a town populated with big-wheeled vehicles known as Monster Machines. In every episode, Blaze and the Monster Machines race into high-octane adventures that explore Science, Technology, Engineering and Math (STEM).