What is the Biggest Casino in Vegas? The flower-filled combo of the Wynn and Encore resorts win the title of the biggest casino in Sin City. This luxury resort betting floor features 191,424-square-feet of space with over 1,800 slot machines and 180 table games to satisfy your gambling fantasy.

Bellagio. The Bellagio is the most famous casino and is recognized as the best casino in Las Vegas. It is located at Las Vegas Strip. The Bellagio resort is under the control and ownership of MGM International Resorts.